Ryan North’s acclaimed run continues as Marvel celebrates 65 years of the World’s Greatest Comics Magazine!Aliens have invaded Earth and been rebuffed by the Fantastic Four many times before. Finally, one of them got wise and invaded Earth where the FF couldn’t defend it: back in the past — in Ancient Rome, to be precise! Johnny and Reed are the only two who can make it there before all of history is erased, but it’s okay! As long as they can defend Earth, push the aliens back and reset history to how it once was, everything should be fine, right? But why is the Human Torch persuading his sister to turn the flesh on his head invisible? So he can impersonate Ghost Rider and settle some old scores! What could possibly go wrong? Then, something goes terribly wrong on Earth, spreading from human to human, unstoppably until everyone is compromised! Everyone, that is, save for Jo and Nicki — the adopted children of Ben and Alicia whose alien Kree and Skrull physiologies leaves them immune. But what can two children do to save an entire world all by themselves? Plus: a 65th-anniversary spectacular starring everyone’s favorite adventurers, spanning centuries of history and a whole universe of scientific progress!COLLECTING: FANTASTIC FOUR (2025) #12-13, #15-18 and material from #14.